Mark A Babizhayev Selected Research

Proteins (Proteins, Gene)

12/2016	Generation of reactive oxygen species in the anterior eye segment. Synergistic codrugs of N-acetylcarnosine lubricant eye drops and mitochondria-targeted antioxidant act as a powerful therapeutic platform for the treatment of cataracts and primary open-angle glaucoma.
1/2016	Telomere Attrition in Human Lens Epithelial Cells Associated with Oxidative Stress Provide a New Therapeutic Target for the Treatment, Dissolving and Prevention of Cataract with N-Acetylcarnosine Lubricant Eye Drops. Kinetic, Pharmacological and Activity-Dependent Separation of Therapeutic Targeting: Transcorneal Penetration and Delivery of L-Carnosine in the Aqueous Humor and Hormone-Like Hypothalamic Antiaging Effects of the Instilled Ophthalmic Drug Through a Safe Eye Medication Technique.
1/2016	Reactive Oxygen Species and the Aging Eye: Specific Role of Metabolically Active Mitochondria in Maintaining Lens Function and in the Initiation of the Oxidation-Induced Maturity Onset Cataract--A Novel Platform of Mitochondria-Targeted Antioxidants With Broad Therapeutic Potential for Redox Regulation and Detoxification of Oxidants in Eye Diseases.
12/2015	Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell-based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telomerase activation therapies.
5/2014	L-carnosine modulates respiratory burst and reactive oxygen species production in neutrophil biochemistry and function: may oral dosage form of non-hydrolized dipeptide L-carnosine complement anti-infective anti-influenza flu treatment, prevention and self-care as an alternative to the conventional vaccination?
8/2012	Structural and functional properties, chaperone activity and posttranslational modifications of alpha-crystallin and its related subunits in the crystalline lens: N-acetylcarnosine, carnosine and carcinine act as alpha- crystallin/small heat shock protein enhancers in prevention and dissolution of cataract in ocular drug delivery formulations of novel therapeutic agents.
3/2012	Biologic activities of molecular chaperones and pharmacologic chaperone imidazole-containing dipeptide-based compounds: natural skin care help and the ultimate challenge: implication for adaptive responses in the skin.
1/2012	Management of the virulent influenza virus infection by oral formulation of nonhydrolized carnosine and isopeptide of carnosine attenuating proinflammatory cytokine-induced nitric oxide production.
1/2011	Water-structuring technology with the molecular chaperone proteins: indicated application of the α-crystallin domains and imidazole-containing peptidomimetics in cosmetic skin care systems or dermatological therapeutic drug carrier formulations.
11/2010	Advanced drug delivery of N-acetylcarnosine (N-acetyl-beta-alanyl-L-histidine), carcinine (beta-alanylhistamine) and L-carnosine (beta-alanyl-L-histidine) in targeting peptide compounds as pharmacological chaperones for use in tissue engineering, human disease management and therapy: from in vitro to the clinic.

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Mark A Babizhayev Research Topics

Disease

29	Cataract (Cataracts) 12/2016 - 01/2002
16	Eye Diseases (Eye Disease) 12/2016 - 01/2009
9	Macular Degeneration (Age-Related Maculopathy) 08/2012 - 01/2009
7	Vision Disorders (Hemeralopia) 01/2016 - 01/2009
7	Diabetes Mellitus 04/2015 - 01/2005
6	Open-Angle Glaucoma (Glaucoma, Open Angle) 12/2016 - 01/2009
6	Inflammation (Inflammations) 03/2014 - 11/2009
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2015 - 11/2010
5	Skin Diseases (Skin Disease) 10/2012 - 01/2010
4	Diabetic Retinopathy (Retinopathy, Diabetic) 06/2012 - 01/2009
4	Glaucoma 07/2011 - 01/2005
3	Wounds and Injuries (Trauma) 12/2015 - 01/2012
3	Infections 05/2014 - 01/2012
3	Human Influenza (Influenza) 05/2014 - 01/2012
2	Diabetes Complications 04/2015 - 10/2012
2	Hyperglycemia 04/2015 - 01/2009
2	Neoplasms (Cancer) 01/2015 - 01/2014
2	Metabolic Diseases (Metabolic Disease) 01/2015 - 01/2015
2	Endophthalmitis (Ophthalmia) 04/2013 - 01/2004
2	Retinal Detachment (Retinal Detachments) 04/2013 - 01/2004
2	Pneumonia (Pneumonitis) 01/2013 - 01/2012
2	Blindness (Hysterical Blindness) 11/2009 - 01/2009
2	vitreous floaters 01/2009 - 01/2005
2	Dry Eye Syndromes (Dry Eye Syndrome) 01/2009 - 01/2005
1	Necrosis 12/2015
1	Diabetic Neuropathies (Diabetic Neuropathy) 04/2015
1	Genetic Predisposition to Disease (Genetic Predisposition) 04/2015
1	Dyslipidemias (Dyslipidemia) 04/2015
1	Ischemic Stroke 01/2015
1	Virus Diseases (Viral Diseases) 05/2014
1	Substance Withdrawal Syndrome (Withdrawal Symptoms) 03/2014
1	Lung Diseases (Lung Disease) 03/2014
1	Chronic Obstructive Pulmonary Disease (COPD) 03/2014
1	Intellectual Disability (Idiocy) 01/2014
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2014
1	Alzheimer Disease (Alzheimer's Disease) 01/2014
1	Cognitive Dysfunction 01/2014
1	Vascular Diseases (Vascular Disease) 01/2014

Drug/Important Bio-Agent (IBA)

30	CarnosineIBA 01/2016 - 01/2005
27	N-acetylcarnosineIBA 12/2016 - 01/2002
18	Lubricant Eye Drops (Artificial Tears)IBA 12/2016 - 01/2004
17	Pharmaceutical PreparationsIBA 01/2015 - 01/2004
13	Proteins (Proteins, Gene)FDA Link 12/2016 - 01/2009
13	AntioxidantsIBA 12/2016 - 10/2008
13	carcinineIBA 04/2015 - 01/2010
12	imidazoleIBA 04/2015 - 01/2010
10	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2016 - 01/2009
10	ProdrugsIBA 01/2014 - 01/2005
9	Free RadicalsIBA 04/2015 - 01/2004
9	DipeptidesIBA 01/2015 - 01/2009
9	Ophthalmic Solutions (Eye Drops)IBA 07/2010 - 01/2005
6	Histidine (L-Histidine)FDA Link 01/2016 - 01/2009
6	LipidsIBA 04/2011 - 01/2004
5	Glutathione (Reduced Glutathione)IBA 04/2015 - 01/2004
5	Biological ProductsIBA 01/2015 - 07/2010
5	Crystallins (Crystallin)IBA 08/2012 - 01/2004
4	Oxidants (Oxidizing Agents)IBA 01/2016 - 04/2011
4	Phospholipids (Phosphatides)FDA LinkGeneric 01/2016 - 01/2005
4	Advanced Glycation End ProductsIBA 04/2015 - 01/2009
4	Peptides (Polypeptides)IBA 04/2015 - 01/2012
4	aminoacyl-histidine dipeptidaseIBA 01/2013 - 01/2009
4	Molecular Chaperones (Chaperone, Molecular)IBA 08/2012 - 11/2010
3	MetalsIBA 01/2015 - 01/2009
3	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2014 - 01/2014
3	Biomarkers (Surrogate Marker)IBA 01/2014 - 11/2011
3	PeptidomimeticsIBA 12/2013 - 01/2011
3	Retinaldehyde (Retinal)IBA 02/2012 - 01/2005
3	HydrazinesIBA 11/2009 - 01/2009
2	Histamine (Histamine Dihydrochloride)FDA Link 01/2016 - 01/2014
2	EnzymesIBA 04/2015 - 01/2009
2	LigandsIBA 05/2014 - 01/2009
2	Peroxynitrous Acid (Peroxynitrite)IBA 01/2013 - 01/2012
2	Superoxides (Superoxide)IBA 01/2013 - 01/2012
2	CytokinesIBA 01/2013 - 01/2012
2	AnserineIBA 01/2013 - 01/2012
2	Oxygen (Dioxygen)IBA 01/2013 - 01/2012
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2013 - 01/2012
2	Amino Acids FDA Link 11/2011 - 07/2010
2	LubricantsIBA 11/2011 - 11/2009
2	Ascorbic Acid (Vitamin C)FDA LinkGeneric 04/2011 - 01/2009
2	Acetylcysteine (Siran)FDA LinkGeneric 07/2010 - 01/2009
2	AldehydesIBA 11/2009 - 01/2009
2	Lipid PeroxidesIBA 01/2009 - 04/2006
2	SolutionsIBA 01/2004 - 01/2002
1	Hormones (Hormone)IBA 01/2016
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2015
1	polyolIBA 04/2015
1	Glutathione Reductase (Glutathione-Disulfide Reductase)IBA 04/2015
1	EpitopesIBA 05/2014
1	Hemagglutinins (Hemagglutinin)IBA 05/2014
1	Complement System Proteins (Complement)IBA 05/2014
1	ChemokinesIBA 05/2014
1	Antiviral Agents (Antivirals)IBA 05/2014
1	Dosage Forms (Dosage Form)IBA 05/2014
1	Nicotine FDA Link 03/2014

Therapy/Procedure

11	Therapeutics 10/2012 - 01/2009
5	Lenses 08/2012 - 01/2005
2	Ophthalmic Administration 12/2015 - 01/2009
2	Nutritional Support (Artificial Feeding) 03/2015 - 01/2014
1	Home Nursing (Nursing, Home) 01/2016